The relation between mortality (all cause ; cancer ; cardiovascular diseases (International Classification of Diseases, Ninth Revision (ICD-9), codes 390-459) ; ischemic heart diseases (ICD-9 codes 410-414)) and exposure to polychlorinated dibenzo-p-dioxins and - furans (PCDD/F) was investigated in a retrospective cohort study.
The cohort consisted of 1,189 male workers in a chemical plant in Hamburg, Federal Republic of Germany, who had produced phenoxy herbicides, chlorophenols, and other herbicides and insecticides known to be contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and other, higher chlorinated dioxins and furans.
The authors reported previously on cancer mortality in this cohort for the follow-up period 1952-1989.
The current study covers the years 1952-1992 and investigates the relation of PCDD/F exposure to mortality using a quantitative estimate of PCDD/F exposure for the whole cohort derived from blood and adipose tissue levels measured in a subgroup (n=190).
Quintiles and deciles of these estimates served as dose parameters in the estimation of relative risks (RRs), using year-of-birth stratified Cox regression.
An unexposed cohort of gas workers served as an external reference group.
The total mortality was elevated in all dose groups.
These findings indicate a strong dose-dependent relation between mortality due to cancer or ischemic heart diseases and exposure to polychlorinated dioxins and furans.
Mots-clés Pascal : Dibenzo-p-dioxine(polychloro), Dibenzofurane(polychloro), Herbicide, Pesticide, Exposition professionnelle, Industrie chimique, Mortalité, Homme, Allemagne(république fédérale), Allemagne, Europe, Médecine travail, Epidémiologie, Rétrospective, Tumeur maligne, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Herbicide, Pesticides, Occupational exposure, Chemical industry, Mortality, Human, West Germany, Germany, Europe, Occupational medicine, Epidemiology, Retrospective, Malignant tumor, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0021930
Code Inist : 002B03G. Création : 01/03/1996.