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  1. Risk factors and cofactors for human T-cell lymphotropic virus type I (HTLV-I) - associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica.

    Article - En anglais

    Human T-cell lymphotropic virus type I (HTLV-I) has been etiologically associated with a neurologic syndrome called HTLV-I-associated myelopathy/tropical spastic paraparesis as well as with adult T-cell leukemia/lymphoma.

    The authors sought to quantify the risk in Jamaica of HAM/TSP associated with HTLV-I infection and cofactors associated with this disease among infected individuals.

    Between 1988 and 1989, prevalent and incident HAM/TSP patients and controls with other neurologic diseases were enrolled in a retrospective study.

    A second control group was composed of HTLV-I-seropositive, asymptomatic carriers in Jamaica, ascertained in a separate study conducted in 1988.

    Although HTLV-I seropositivity was not a component of the case definition for HAM/TSP, all 43 HAM/TSP patients were HTLV-I seropositive compared with two of the controls with other neurologic diseases.

    Given HTLV-I seropositivity, one cofactor associated with the risk of HAM/TSP was young age at initial heterosexual intercourse (odds ratio=4.00,95% confidence interval 1.29-12.46 for individuals aged ¾15 ; odds ratio=4.26,95% confidence interval 1.41-12.90 for individuals aged 16-17 years at initial intercourse).

    Neither an early age at initial sexual intercourse or the number of lifetime sexual partners was a risk factor for adult T-cell leukemia/lymphoma.

    These data support the hypothesis that HAM/TSP is associated with sexually acquired HTLV-I infection, whereas adult T-cell leukemia/lymphoma is not.

    Mots-clés Pascal : Paraparésie, Spasme, Myélopathie, Virus HTLV1, Retroviridae, Virus, Leucémie cellule T adulte, Virose, Infection, Lymphome non hodgkinien, Homme, Epidémiologie, Facteur risque, Jamaïque, Antilles, Amérique Centrale, Amérique, Maladie sexuellement transmissible, Système nerveux pathologie, Trouble neurologique, Trouble moteur, Parésie, Hémopathie maligne, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Paraparesia, Spasm, Myelopathy, HTLV-I virus, Retroviridae, Virus, Adult T cell leukemia, Viral disease, Infection, Non Hodgkin lymphoma, Human, Epidemiology, Risk factor, Jamaica, West Indies, Central America, America, Sexually transmitted disease, Nervous system diseases, Neurological disorder, Motor system disorder, Paresis, Malignant hemopathy, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0021682

    Code Inist : 002B17H. Création : 01/03/1996.