A population-based, case-control study of pancreatic cancer based on direct interviews with 307 white and 179 black incident cases and 1164 white and 945 black population controls was conducted in three areas of the United States to determine the role alcohol drinking plays as a risk factor for pancreatic cancer and to estimate the extent to which it may explain the higher incidence of pancreatic cancer in blacks compared to whites.
Our findings indicate that alcohol drinking at the levels typically consumed by the general population of the United States is probably not a risk factor for pancreatic cancer.
Our data suggest, however, that heavy alcohol drinking may be related to pancreatic cancer risk.
Among men, blacks and whites who drank at least 57 drinks/week had odds ratios (ORs) of 2.2 [95% confidence interval (CI)=0.9-5.6] and 1.4 (95% CI=0.6-3.2), respectively.
Compared to whites, blacks had significantly higher ORs associated with heavy alcohol drinking (=57 drinks/week) in men (P=0.04) and with moderate-to-heavy drinking (=8 drinks/week) in women (P=0.03).
Additional research is needed to determine whether heavy alcohol drinking is causally related to pancreatic cancer and whether the risk of alcohol-related pancreatic cancer is greater in blacks than in whites.
Mots-clés Pascal : Ethanol, Alcoolisme, Facteur risque, Tumeur maligne, Pancréas, Homme, Race, Négroïde, Caucasoïde, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Toxicité, Carcinogène, Pancréas pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Ethanol, Alcoholism, Risk factor, Malignant tumor, Pancreas, Human, Race, Negroid, Caucasoid, United States, North America, America, Epidemiology, Toxicity, Carcinogen, Pancreatic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0021161
Code Inist : 002B13C01. Création : 01/03/1996.