Urinary excretions of high molecular weight bêta-thromboglobulin and albumin are independently associated with coronary heart disease in women, a nested case-control study of middle-aged women in the Diagnostisch Onderzoek Mammacarcinoom (DOM) cohort, Utrecht, Netherlands.
Increased plasma levels of bêta-thromboglobulin, a platelet activation marker, are observed in coronary artery disease.
Urinary albumin excretion, a marker of endothelial cell perturbation, is related to cardiovascular disease in diabetes.
To test the value of these markers in predicting forthcoming coronary disease, the relations between urinary excretions of high molecular weight bêta-thromboglobulin (HMW-bêtaTG) and albumin and subsequent coronary disease in a cohort of 15,484 middle-aged women were investigated in a nested case-control study.
Baseline questionnaire data and urine samples were available from a breast cancer screening program in Utrecht during 1982-1985.
Cases were Utrecht hospital admissions for myocardial infarction (n=50) or angiographically confirmed coronary disease (n=28) from 1982-1985 to 1990-1991.
Classifying events occurred a median of 5.1 years after baseline.
Controls were a random sample from the cohort, individually case matched for baseline examination date and age, at a 1 : 2 ratio.
HMW-bêtaTG/creatinine ratios (ng/mmol, mean ± standard error) were 5.3 ± 0.3 in cases and 4.7 ± 0.3 in controls ; albumin/creatinine ratios (mg/mmol, median) were, respectively, 0.37 and 0.22.
Mots-clés Pascal : Cardiopathie coronaire, Epidémiologie, Prédiction, Thromboglobuline bêta, Albumine, Excrétion, Urine, Pays Bas, Europe, Homme, Femelle, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Epidemiology, Prediction, beta-Thromboglobulin, Albumin, Excretion, Urine, Netherlands, Europe, Human, Female, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0020478
Code Inist : 002B12A03. Création : 01/03/1996.