Exploring the role of diet in modifying the effect of known disease determinants : application to risk factors of liver cirrhosis.
The analysis of the combined effects of nutritional factors with other putative disease determinants in log-linear or logistic models is methodologically complicated by the strong multicollinearity between nutritional factors, resulting in poor precision in estimating the parameters.
The generally used multiplicative structure is not always the most appropriate for describing the resulting joint effect of two or more factors on the disease risk.
The authors addressed such problems in a case-control study assessing the interactions between alcohol intake, chronic hepatitis C virus (HCV) infection, and nutrient intake on the risk of liver cirrhosis.
During the period from November 1989 to May 1990,282 patients admitted to the medical departments of the hospitals of the Province of L'Aquila were enrolled.
The Breslow and Storer parametric family of relative risk functions showed that a multiplicative structure was the most adequate to describe the joint effect of nutritional pattern with alcohol intake and/or chronic HCV infection, whereas an additive structure best described the joint effect of chronic HCV infection and alcohol intake.
In conclusion, the analysis of principal components and the Breslow and Storer family are useful tools to explore the role of diet on disease risk when precise pathogenic knowledge is not available.
Mots-clés Pascal : Cirrhose, Foie, Epidémiologie, Régression logistique, Modèle statistique, Méthodologie, Facteur risque, Hépatite virale C, Virose, Infection, Alcoolisme, Alimentation, Glucide, Lipide, Protéine, Homme, Appareil digestif pathologie, Foie pathologie, Italie, Europe
Mots-clés Pascal anglais : Cirrhosis, Liver, Epidemiology, Logistic regression, Statistical model, Methodology, Risk factor, Viral hepatitis C, Viral disease, Infection, Alcoholism, Feeding, Carbohydrate, Lipids, Proteins, Human, Digestive diseases, Hepatic disease, Italy, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0020476
Code Inist : 002B13C03. Création : 01/03/1996.