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  1. Intrafamilial transmission of hepatitis C virus among the population of an endemic area of Japan.

    Article - En anglais

    Objectives

    - To assess the role of intrafamilial transmission of hepatitis C virus (HCV) among general populations.

    Design and Setting

    - Cross-sectional study in an HCV-endemic area of Japan.

    Participants

    - A total of 1122 residents (mean age, 41.7 years ; range, 0 to 80 years), including 359 mother-child pairs and 234 pairs of spouses.

    Main Outcome Measures

    - Antibody to HCV (anti-HCV) was examined using second-generation anti-HCV testing by passive hemagglutination assay.

    Hepatitis C virus RNA was detected by polymerase chain reaction with primers deduced from the 5'-noncoding region and HCV genotypes by reaction with type-specific primers deduced from the HCV core gene.

    Results

    - Prevalence of anti-HCV was 14.1% (158/1122), and HCV RNA was detected in 82.9% of those who tested positive for anti-HCV.

    Prevalence of anti-HCV increased with advancing age, but no anti-HCV was found among 312 persons younger than 20 years.

    Of the 53 children with anti-HCV-positive mothers, three were positive for anti-HCV, all were older than 20 years, and all had a history of surgical treatment.

    Hepatitis C virus RNA was found in one mother-child pair but with different HCV genotypes.

    Both spouses were positive for anti-HCV in 17 of 234 pairs.

    Conclusions

    - While HCV is highly endemic in this area, neither vertical nor horizontal transmission between spouses seems to play an important role in its spread.

    Mots-clés Pascal : Hépatite virale C, Transmission, Milieu familial, Incidence, Transmission mère enfant, Epidémiologie, Homme, Japon, Virose, Infection, Asie, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Viral hepatitis C, Transmission, Family environment, Incidence, Mother to child transmission, Epidemiology, Human, Japan, Viral disease, Infection, Asia, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0015514

    Code Inist : 002B30A01A2. Création : 01/03/1996.