Background and Purpose This report examincs the relationship between lung function and risk of major strokc events (fatal and nonfatal).
Methods We completed a prospective study of 7735 men aged 40 to 59 years at screening selected at random from one general practice in each of 24 British towns.
Results During the mean follow-up period of 14.8 years, there were 277 major stroke events in the 7650 men with data on forced expiratory volume in I second (FEV1).
After exclusion of 499 men with definite myocardial infarction, stroke, or atrial fibrillation at screening, 7151 mcn experienccd 239 major stroke events.
Lowcr levels of FEV1 were associated with a significant increase in risk of stroke even after adjustment for age, smoking, social class, physical activity, alcohol intake, systolic blood pressure, antihypertensive treatment, diabetes, and precxisting ischemic heart disease.
Relative risk in the low third (<3.10 L) versus high third (>3.65 L) was 1.4 (95% confidence interval, 1.0 to 2.0).
The inverse association between FEV1 and stroke was only apparent in older men, current nonsmokers, hypertensive men, and men with preexisting ischemic heart disease.
Lower FEV1 was associated with higher rates of stroke in hypertensive men irrespective of smoking status.
Conclusions Lower levels of FEV1 are associated with an increased risk of stroke in those already at high risk, eg, those with ischemic heart disease or hypertension.
Mots-clés Pascal : Accident cérébrovasculaire, Fonction respiratoire, Facteur risque, Epidémiologie, Angleterre, Grande Bretagne, Royaume Uni, Europe, Homme, Mâle, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Stroke, Lung function, Risk factor, Epidemiology, England, Great Britain, United Kingdom, Europe, Human, Male, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0012892
Code Inist : 002B17C. Création : 01/03/1996.