Serum, breast milk, and infant antibody after maternal immunisation with pneumococcal vaccine.
Pneumococci are a leading cause of severe bacterial disease in infants and children world wide.
A possible means of protecting infants in the first few months of life is immunisation of the mother during pregnancy.
We prospectively assessed pneumococcal immunisation of pregnant women to determine the amount of pneumococcal antibody transmitted to the infants in serum and milk and the half-life of the passively acquired antibody.
Healthy pregnant women in Dhaka, Bangladesh, were randomised to receive pneumococcal or meningococcal vaccine with routine prenatal tetanus immunisation at 30-34 weeks of gestation.
Serum and breast milk specimens from the mothers and sera from infants were collected up to 22 weeks of age and assayed for specific serum IgG, IgG1, and IgG2 and for milk IgA antibodies to pneumococcal serotypes 6B and 19F. 55 mothers and 56 infants were followed from birth to five months.
Women who received pneumococcal vaccine had geometric mean antibody increases of 2.6 and 3.4 to types 6B and 19F, respectively.
The mean infant/maternal antibody ratios were 0.56 and 0.59 (range 0.11-1.46) for these serotypes.
Infant cord antibody titres correlated with maternal titres.
Infant/maternal IgG ratios correlated with the interval between immunisation and birth and were higher for specific IgG1 than for IgG2.
Mots-clés Pascal : Vaccin, Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bactérie, Neisseria meningitidis, Neisseriaceae, Nouveau né, Homme, Lait maternel, Allaitement, Anticorps, Mère, Prévention, Gestation, Bengla Desh, Asie, Bactériose, Infection, Nouveau né pathologie
Mots-clés Pascal anglais : Vaccine, Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bacteria, Neisseria meningitidis, Neisseriaceae, Newborn, Human, Breast milk, Breast feeding, Antibody, Mother, Prevention, Pregnancy, Bangladesh, Asia, Bacteriosis, Infection, Newborn diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0008440
Code Inist : 002B05B02E. Création : 01/03/1996.