However, not all cases of SIL progress, and most of the mild lesions spontaneously regress.
Factors that govern regression, persistence, and progression of SIL are poorly understood.
Our analysis sought to identify factors that determined persistence or regression of SIL.
Seventy subjects with histopathologically confirmed cervical dysplasia were followed at 3-month intervals for 15 months.
At each visit, the cervix was evaluated by Pap smear and colposcopy, and exfoliated cervicovaginal cells were analyzed for human papillomavirus (HPV) DNA.
For each subject, data from every two consecutive visits were grouped as a pair.
Persistent SIL was considered present if a lesion was detected at a visit (t) as well as at the next visit (t+1) and absent if a lesion was detected at visit t but not at visit t+1. A statistical model for time-dependent data correlated persistent SIL with various risk factors.
Age, ethnicity, education, sexual behavior, smoking, and the use of oral contraceptives did not correlate with persistent SIL.
HPV infection and its associated cervical lesions tend to occur concurrently, and type-specific persistent HPV infection, particularly with a high viral load, produces chronic cervical dysplasia.
Implications : The natural history of genital HPV infection directly influences the prognosis of cervical dysplasia as measured by persistence of the lesion.
Mots-clés Pascal : Dysplasie, Col utérus, Facteur risque, Epidémiologie, New York, Etats Unis, Amérique du Nord, Amérique, Virose, Infection, Vagin, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Persistance, Homme, Lésion précancéreuse, Appareil génital femelle pathologie, Vagin pathologie
Mots-clés Pascal anglais : Dysplasia, Uterine cervix, Risk factor, Epidemiology, New York, United States, North America, America, Viral disease, Infection, Vagina, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Persistence, Human, Premalignant lesion, Female genital diseases, Vaginal diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0007310
Code Inist : 002B20C02. Création : 01/03/1996.