The functional status of the immune system was investigated in a group of 71 workers exposed to styrene and in 65 control subjects, recruited according to the same selection criteria and comparable as to sex, age, and confounding variables.
Air and biological monitoring were used to characterize styrene exposure (median of the main urinary metabolites in the « next-morning » spot samples : 106 mg/g creatinine).
Phenotypic analysis of peripheral blood lymphocytes (PBL) by automated flow cytometry revealed a reduced proportion of T lymphocyte subsets (CD3+CD4+and CD4+45+), with no changes in CD8+and a higher proportion of B lymphocytes (CD19+) among styrene-exposed workers.
The exposed workers showed a higher proportion of activation markers, namely DR and interleukin-2 receptors (CD25).
Immunoglobulin subclasses were comparable in the two groups.
An increased prevalence of abnormally low values was apparent for CD2+CD3+CD4+CD4+45+and CD11b subsets among workers exposed to styrene, whereas CD19+DR+and CD25+showed an increased prevalence of abnormally high values.
Natural killer-related phenotypes (CD56+CD56+16+and CD56+16-) were more expressed among styrene workers, with average increase of 30%.
Mots-clés Pascal : Styrène, Exposition professionnelle, Homme, Immunopathologie, Système immunitaire, Lymphocyte, Cellule NK, Toxicité, Médecine travail
Mots-clés Pascal anglais : Styrene, Occupational exposure, Human, Immunopathology, Immune system, Lymphocyte, Natural killer cell, Toxicity, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0006557
Code Inist : 002B03L06. Création : 01/03/1996.