Baseline measurements for a population-based prospective cohort study were used to assess the association between family history of enlarged prostate and urinary symptoms.
Between December 1989 and March 1991, a group of randomly selected men aged 40-79 years from Olmsted County, Minnesota, was administered a previously validated questionnaire that included questions with wording close to that of the American Urological Association's Symptom Index.
A detailed family history of an enlarged prostate was obtained by personal interview, and peak urinary flow rates were measured for each participant.
Of the 2,119 men, 440 (21 percent) reported a family history of an enlarged prostate.
The age-adjusted odds of having moderate or severe urinary symptoms were elevated among those with a family history relative to those without.
With simultaneous control for effects of age and worry about urologic function, the odds ratio remained at 1.3 (95 percent confidence interval 1.0-1.6).
Furthermore, this risk was greater for men with relatives diagnosed at a younger age.
Men with a family history were also 1.3 times as likely to have an impaired peak urinary flow rate.
These findings suggest that men with a family history of an enlarged prostate may be at increased risk for development of symptoms and signs suggestive of benign prostatic hyperplasia and that this risk is greater in men with relatives diagnosed at a younger age.
Mots-clés Pascal : Hyperplasie, Prostate, Histoire familiale, Rappel, Autoévaluation, Homme, Mâle, Minnesota, Etats Unis, Amérique du Nord, Amérique, Age, Méthodologie, Etude familiale, Epidémiologie, Tumeur bénigne, Prostate pathologie, Appareil génital mâle pathologie, Appareil urinaire pathologie
Mots-clés Pascal anglais : Hyperplasia, Prostate, Family story, Recall, Self evaluation, Human, Male, Minnesota, United States, North America, America, Age, Methodology, Family study, Epidemiology, Benign neoplasm, Prostate disease, Male genital diseases, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0006070
Code Inist : 002B14D02. Création : 01/03/1996.