The objectives of the study were to assess whether the epidemiologic data support a relation between dietary calcium intake and blood pressure, to obtain a quantitative estimate of the difference in blood pressure for a given difference in dietary calcium intake, and to assess the public health implications.
A meta-analysis of published data (January 1983 to November 1993) that investigated the association between dietary calcium intake and blood pressure in different populations around the world was performed.
Of 63 population studies identified, 23 were suitable for a quantitative overview (total n=38,950).
Unadjusted regression coefficients (95% confidence intervals) were obtained.
Pooled unadjusted regression coefficients (95% confidence intervals) were then computed weighting each individual study by the inverse of its variance.
Tests of heterogeneity and sensitivity analysis were carried out, and the possibility of publication bias was assessed.
These data are consistent with an inverse association between dietary calcium intake and blood pressure.
However, the size of the estimate, the observed heterogeneity among studies, and the possibility of confounding and publication bias indicate that an increase in calcium intake above the Recommended Dietary Allowance is not recommended at population level for the prevention and treatment of high blood pressure.
Mots-clés Pascal : Alimentation, Régime alimentaire enrichi, Calcium, Epidémiologie, Homme, Pression sanguine, Hémodynamique, Métaanalyse, Analyse statistique
Mots-clés Pascal anglais : Feeding, Supplemented diet, Calcium, Epidemiology, Human, Blood pressure, Hemodynamics, Metaanalysis, Statistical analysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0006066
Code Inist : 002B29B. Création : 01/03/1996.