Sex hormones play a major role in determining the risk of cardiovascular disease.
While several studies have shown that reduced sex hormone-binding globulin is associated with an atherogenic pattern of lipoproteins and increased glucose concentrations in premenopausal women, little data are available examining the association of sex hormone-binding globulin and sex hormones with cardiovascular risk factors in postmenopausal women, a group with high rates of cardiovascular disease.
The investigators hypothesized that in postmenopausal women decreased sex hormone-binding globulin and increased testosterone would be associated with an atherogenic pattern of cardiovascular risk factors.
The sex hormone-binding globulin, total and free testosterone, estrone, and dehydroepiandrosterone sulfate (DHEA-SO4) in 253 postmenopausal women who were not taking hormones were measured in a population-based study, the Beaver Dam Eye Study (Beaver Dam, Wisconsin, 1988-1990).
Sex hormone-binding globulin was significantly inversely correlated with body mass index (r=-0.53, p<0.001), glycosylated hemoglobin (r=-0.34, p<0.001), and diastolic blood pressure (r=-0.25, p<0.01), and positively correlated with high density lipoprotein cholesterol (HDL cholesterol) (r=0.31, p<0.001), and HDL cholesterol/total cholesterol (r=0.31, p<0.001).
Total (r=-0.20, p<0.01) and free (r=-0.14, p<0.05) testosterone were significantly inversely correlated with HDL cholesterol/total cholesterol ratio.
Mots-clés Pascal : Oestrone, Testostérone, Déhydroépiandrostérone sulfate, SBP, Epidémiologie, Indice masse corporelle, Cholestérol HDL, Pression sanguine, Hémodynamique, Facteur risque, Appareil circulatoire, Homme, Femelle, Postménopause, Lipide, Etats Unis, Oestrogène, Hormone stéroïde sexuelle, Hormone ovarienne, Androgène, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Estrone, Testosterone, Dehydroepiandrosterone sulfate, Sex hormone binding protein, Epidemiology, Body mass index, Cholesterol HDL, Blood pressure, Hemodynamics, Risk factor, Circulatory system, Human, Female, Postmenopause, Lipids, United States, Estrogen, Sex steroid hormone, Ovarian hormone, Androgen, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0006065
Code Inist : 002B30A09. Création : 01/03/1996.