Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.
We conducted a case-control study of patients with incident lung cancer and population control subjects to examine the association between homozygous deletion of the GSTM1 gene and lung cancer risk among African-Americans and Caucasians.
At 35 hospitals in Los Angeles County, California, we identified patients with a first diagnosis of lung cancer between September 1,1990, and January 6,1994.
Of the 859 potentially eligible case patients, 207 had died by the time their physicians had received our request for permission to contact them.
For patients with all lung cancers combined, the GSTM1 null genotype was associated with an OR of 1.29 (95% CI=0.94-1.77).
The OR was similar among African-Americans (OR=1.20 ; 95% CI=0.72-2.00) and Caucasians (OR=1.37 ; 95% CI=0.91-2.06).
The association was strongest for squamous cell carcinoma (OR=1.57 ; 95% CI=0.93-2.63).
We observed an OR of 1.77 for the GSTM1 null genotype in relation to lung cancer risk among smokers of less than 40 pack-years, but no association among heavier smokers.
Our data do not support a substantial association between homozygous deletion of the GSTM1 gene and the risk of lung cancer overall in this population.
However, our data do suggest an elevated risk for lighter smokers with this genotype.
Implications : Because the power of our analyses within strata of lifetime smoking history was limited, larger studies will be needed to confirm these findings.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Facteur risque, Epidémiologie, Glutathione transferase, Transferases, Enzyme, Polymorphisme, Gène, Délétion, Noir américain, Caucasoïde, Californie, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Risk factor, Epidemiology, Glutathione transferase, Transferases, Enzyme, Polymorphism, Gene, Deletion, Black American, Caucasoid, California, United States, North America, America, Human, Respiratory disease, Lung disease, Bronchus disease, Case control study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0006061
Code Inist : 002B11A. Création : 01/03/1996.