Maternal asthma and idiopathic preterm labor.
Previous studies suggest that women with asthma are at increased risk of preterm birth.
Moreover, drugs used to treat asthma are also used to treat preterm labor.
The authors carried out a case-control study of 555 women from three hospital centers with idiopathic preterm labor (<37 weeks), including two overlapping subsamples : cases with early idiopathic preterm labor (<34 weeks) and cases with idiopathic recurrent preterm labor.
Controls were matched to cases according to race and smoking history prior to and during pregnancy.
All subjects responded in person to questions about atopic, respiratory, obstetric, and sociodemographic histories.
Subjects in the early and recurrent preterm labor subsamples were also asked to undergo spirometric testing with methacholine challenge 6-12 weeks after delivery.
Cases were significantly more likely to report histories of asthma symptoms and physician-diagnosed asthma than controls, particularly those cases with recurrent preterm labor.
No significant associations were observed, however, with methacholine responsiveness.
These results could not be explained by residual confounding by smoking or other variables, nor by selective recall of asthma symptoms and histories by cases.
Women with asthma are at increased risk of idiopathic preterm labor.
The fact that no such association was seen with methacholine responsiveness suggests that nonatopic, noncholinergic mechanisms may link bronchial and uterine smooth muscle lability.
Mots-clés Pascal : Poids naissance faible, Nourrisson, Homme, Epidémiologie, Asthme, Mère, Québec, Canada, Amérique du Nord, Amérique, Gestation pathologie, Prématurité, Nouveau né pathologie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Low birth weight, Infant, Human, Epidemiology, Asthma, Mother, Quebec, Canada, North America, America, Pregnancy disorders, Prematurity, Newborn diseases, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0005961
Code Inist : 002B20G03. Création : 01/03/1996.