Primary hyperoxaluria. Workshop. Lyon FRA, 1994/10/21.
Primary hyperoxaluria type 1 (PH1) always leads to oxalate accumulation throughout the body (oxalosis).
Currently available epidemiological data only concern patients with end-stage kidney disease requiring renal replacement therapy (RRT).
French nephrologists have been questioned about PH1 patients who were under their care between 1988 and 1992.
Exhaustive answers were obtained and 90 cases of PH1 were collected.
The average prevalence rate of PH1 was 1.05/106 and its average incidence rate was 0.12/106/year.
The median age at onset was 5 years (0-63) and initial symptoms involved the urinary tract in 82% of the cases.
Half the patients were younger than 10 years at the time of diagnosis on the basis of urine oxalate (89%) ± urine glycolate (43%) ± plasma oxalate (71%) ± hepatic alanine : glyoxylate aminotransferase activity (48%). At the time of the survey, 36% of patients were on a conservative treatment, 37% were transplanted and 27% were on maintenance haemodialysis ; the crude mortality rate was 19% (median age 36 years).
Patients on dialysis started RRT at a median age of 25 years.
Transplanted patients received their first transplant at a median age of 29.5 years.
These data confirm the rarity of PH1 together with its poor prognosis ; as shown in the European experience, early combined liver-kidney transplantation seems to be the best therapeutic proposal.
Mots-clés Pascal : Hyperoxalurie, Primaire, Epidémiologie, Homme, Oxalate, Métabolisme pathologie, Maladie héréditaire, Enzymopathie
Mots-clés Pascal anglais : Hyperoxaluria, Primary, Epidemiology, Human, Oxalate, Metabolic diseases, Genetic disease, Enzymopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0004645
Code Inist : 002B22D05. Création : 01/03/1996.