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  1. Epidemic optic neuropathy in Cuba : clinical characterization and risk factors.

    Article - En anglais

    Background

    From 1991 to 1993, epidemic optic and peripheral neuropathy affected more than 50,000 people in Cuba.

    The number of new cases decreased after the initiation of vitamin supplementation in the population.

    In September 1993, Cuban and U.S. investigators conducted a study to characterize and identify risk factors for the optic form of the syndrome.

    Methods

    We conducted ophthalmologic and neurologic examinations, assessed exposure to potential toxins, administered a semiquantitative food-frequency questionnaire, and assessed serum measures of nutritional status in 123 patients with severe optic neuropathy, matched for sex and age to randomly chosen normal subjects.

    Results

    In the case patients, prominent clinical features were subacute loss of visual acuity with field defects, diminished color vision, optic-nerve pallor, and decreased sensitivity to vibration and temperature in the legs.

    Tobacco use, particularly cigar smoking, was associated with an increased risk of optic neuropathy.

    The risk was reduced among subjects with higher dietary intakes of methionine, vitamin B12, riboflavin, and niacin and higher serum concentrations of antioxidant carotenoids.

    Conclusions

    The epidemic of optic and peripheral neuropathy in Cuba between 1991 and 1993 appears to be linked to reduced nutrient intake caused by the country's deteriorating economic situation and the high prevalence of tobacco use.

    Mots-clés Pascal : Neuropathie, Nerf optique, Neuropathie périphérique, Epidémie, Tabagisme, Cigare, Hypovitaminose, Cuba, Antilles, Amérique Centrale, Amérique, Facteur risque, Homme, Oeil pathologie, Système nerveux pathologie, Nerf crânien pathologie, Nerf périphérique pathologie, Métabolisme pathologie, Carence alimentaire

    Mots-clés Pascal anglais : Neuropathy, Optic nerve, Peripheral neuropathy, Epidemic, Tobacco smoking, Cigar, Hypovitaminosis, Cuba, West Indies, Central America, America, Risk factor, Human, Eye disease, Nervous system diseases, Cranial nerve disease, Peripheral nerve disease, Metabolic diseases, Nutritional deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0003115

    Code Inist : 002B09L. Création : 01/03/1996.