Risk of renal-cell cancer in relation to use of diuretics, other anti-hypertensive medications and hypertension was assessed in a multi-center, population-based, case-control study conducted in Australia, Denmark, Germany, Sweden and the United States, using a shared protocol and questionnaire.
A total of 1,732 histologically confirmed cases and 2,309 controls, frequency-matched to cases by age and sex, were interviewed.
The association between renal-cell cancer and the drugs was estimated by relative risks (RRs) and 95% confidence intervals (CIs).
Risks were increased among users of diuretics and other anti-hypertensive medications.
After adjustment for hypertension, risk for diuretics was reduced to unity, except among long-term (15+years) users.
Risk for use of non-diuretic anti-hypertensive drugs remained significantly elevated and increased further with duration of use.
Overall risk was not enhanced when both classes of medications were used.
Excess risk was not restricted to any specific type of diuretic or anti-hypertensive drug and no trend was observed with estimated lifetime consumption of any particular type of product.
The RR for hypertension after adjustment for diuretics and other anti-hypertensive medications was 1.4 (95% CI=1.2-1.7), although among non-users of any anti-hypertensive medications, there was little excess risk associated with a history of hypertension.
Mots-clés Pascal : Hypernéphrome, Homme, Epidémiologie, Facteur risque, Hypertension artérielle, Chimiothérapie, Antihypertenseur, Diurétique, Antagoniste calcium, Bloquant bêta-adrénergique, Sympatholytique, Etude multicentrique, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne, Appareil circulatoire pathologie, Inhibiteur angiotensin converting enzyme, Etude cas témoin
Mots-clés Pascal anglais : Grawitz tumor, Human, Epidemiology, Risk factor, Hypertension, Chemotherapy, Antihypertensive agent, Diuretic, Calcium antagonist, Beta blocking agent, Sympatholytic, Multicenter study, Urinary system disease, Renal disease, Malignant tumor, Cardiovascular disease, ACE inhibitor, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0592731
Code Inist : 002B14D01. Création : 01/03/1996.