logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. A clinical and immunological study on 92 workers occupationally exposed to anhydrides.

    Article - En anglais

    This study aimed at investigating sensitizing and hazardous effects of a new acid anhydride, pyromellitic dianhydride (PMDA), in addition to those of phthalic anhydride, maleic anhydride and trimellitic anhydride, in a group of 92 exposed workers in two German chemical plants.

    Of the 92 workers, 56 reported work-related complaints with a predominance of phlegm and dyspnoea in those exposed to anhydride dust for less than 1 year.

    Haemorrhagic rhinitis occurred only after a prolonged exposure of more than 15 years.

    Specific IgE antibodies to anhydride-HSA conjugates could be detected in 15 exposed subjects, 12 of whom had work-related symptoms.

    The IgE-positive group had significantly more impaired lung function parameters than the IgE-negative group.

    The proportion of IgE-positive subjects was highest in the groups with dyspnoea (5/18), cough (6/24) and rhinitis (11/44) whereas only 1 of 11 workers with haemorrhagic rhinitis had such antibodies.

    A follow-up study of 23 affected workers was performed after 10 months to assess clinical symptoms, lung function and IgE antibody levels.

    This follow-up study showed the absence of obstructive ventilation patterns in three out of six subjects in addition to cessation of symptoms in most initially affected workers who were no longer exposed.

    On the other hand, 14 workers under continuous exposure had comparable pathological findings on re-examination.

    Mots-clés Pascal : Anhydride organique, Exposition professionnelle, Homme, Industrie chimique, Allemagne, Europe, Rhinite, IgE, Allergie, Toxicité, Fonction respiratoire, Appareil respiratoire pathologie, Médecine travail, Immunopathologie, ORL pathologie, Nez pathologie

    Mots-clés Pascal anglais : Organic anhydride, Occupational exposure, Human, Chemical industry, Germany, Europe, Rhinitis, IgE, Allergy, Toxicity, Lung function, Respiratory disease, Occupational medicine, Immunopathology, ENT disease, Nose disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0592613

    Code Inist : 002B03L06. Création : 01/03/1996.