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  1. Assessment of a universal, school-based hepatitis B vaccination program.

    Article - En anglais

    Objective

    - To assess a hepatitis B vaccination program offered to all grade 6 students in British Columbia in 1992.

    Design

    - Cohort study.

    Setting

    - British Columbia, Canada.

    Participants

    - All grade 6 students were offered vaccine.

    Subsets of 454 and 259 students participated in studies of minor adverse events and seroresponse, respectively. intervention. - The vaccine used was Engerix-B, 20 mug, given at intervals of 0,1, and 6 months.

    Main Outcome Measures

    - Province-wide acceptance and series completion rates and reports of severe adverse events.

    Minor adverse events and immunogenicity in subsamples.

    Results

    - A total of 127 922 vaccine doses were administered.

    Initial enrollment totaled 43 358 students or 95.4% of those eligible.

    The series was completed by 41 594 students (95.6%). Minor adverse events were infrequent in the cohort assessed : no absenteeism or physician visits resulted from vaccination.

    Sixty-nine reported severe adverse events met surveillance definitions, the major categories being injection site reactions (23% of reports), fainting (20%), and rashes (17%). There was one instance of anaphylaxis.

    Only 13 of these events resulted in recommendations to discontinue the series.

    Of students tested following the series, 98% had levels of antibody to hepatitis B surface antigen considered to be protective (=10 IU/L), the geometric mean titer being 690 IU/L (95% confidence interval, 498 to 957 IU/L).

    Mots-clés Pascal : Hépatite virale, Virus hépatite B, Programme, Vaccination, Campagne de masse, Age scolaire, Prévention, Attitude, Enfant, Virose, Infection, Hepadnaviridae, Virus, Homme, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Viral hepatitis, Hepatitis B virus, Program, Vaccination, Mass campaign, School age, Prevention, Attitude, Child, Viral disease, Infection, Hepadnaviridae, Virus, Human, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0591560

    Code Inist : 002B30A01C. Création : 01/03/1996.