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  1. The incidence and natural history of knee osteoarthritis in the elderly : the Framingham Osteoarthritis Study.

    Article - En anglais


    To determine the incidence of radiographic knee osteoarthritis (OA) and symptomatic OA (symptoms plus radiographic OA), as well as the rate of progression of preexisting radiographic OA in a population-based sample of elderly persons.


    Framingham Osteoarthritis Study subjects who had knee radiographs and had answered questions about knee symptoms in 1983-1985 were reexamined in 1992-1993 (mean 8.1-year interval) using the same protocol.

    Subjects were defined as having new (incident) radiographic OA if they developed grade =2 OA (at least definite osteophytes or definite joint space narrowing).

    New symptomatic OA was present if subjects developed a combination of knee symptoms and grade =2 OA.

    Progressive OA was diagnosed when radiographs showing grade 2 disease at baseline showed grade =3 disease on followup.


    Of 1,438 participants in the original study, 387 (26.9%) died prior to followup.

    Of the 1,051 surviving subjects, 869 (82.7%) participated in the followup study (mean ± SD age 70.8 ± 5.0 at baseline).

    Rates of incident disease were 1.7 times higher in women than in men (95% confidence interval [CI] 1.0-2.7), and progressive disease occurred slightly more often in women (relative risk=1.4 ; 95% CI 0.8-2.5) but rates did not vary by age in this sample.

    Among women, approximately 2% per year developed incident radiographic disease, 1% per year developed symptomatic knee OA, and about 4% per year experienced progressive knee OA.

    Mots-clés Pascal : Arthrose, Genou, Vieillard, Homme, Incidence, Epidémiologie, Evolution, Age, Sexe, Etude longitudinale, Membre inférieur, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative

    Mots-clés Pascal anglais : Osteoarthritis, Knee, Elderly, Human, Incidence, Epidemiology, Evolution, Age, Sex, Follow up study, Lower limb, Diseases of the osteoarticular system, Arthropathy, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0590077

    Code Inist : 002B15E. Création : 01/03/1996.