Biologic sex as a risk factor for Helicobacter pylori infection in healthy young adults.
Diseases associated with Helicobacter pylori infection, such as peptic ulcer disease and gastric cancer, afflict men more frequently than women.
No study, however, has demonstrated any difference in sex-specific rates of H. pylori infection.
In a healthy population undergoing multiphasic health evaluations in 1992-1993 as members of the Kaiser Permanente Medical Care Program of Northern California, adults aged 20-39 years were screened for antibodies to H. pylori infection using a serum enzyme-linked immunosorbent assay and were surveyed with regard to their demographic characteristics and health practices.
Men consistently had a higher prevalence of antibodies across all strata of race/ethnicity, age, education, and income, and in multivariate analysis male sex remained significantly associated with infection (odds ratio=2.0,95% confidence interval 1.2-3.1).
African-American race, Hispanic ethnicity, increasing age, lower levels of education, and birth in a developing country were also associated with infection in multivariate analysis.
Data from previously reported seroprevalence studies support a tendency for men to have a higher risk of infection.
The higher prevalence of infection among young males as observed in Northern California may account in part for the increased incidence of H. pylori-related diseases among men in later decades of life.
Mots-clés Pascal : Bactériose, Infection, Estomac, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Epidémiologie, Sexe, Adulte jeune, Homme, Sérologie, Ethnie, Californie, Etats Unis, Amérique du Nord, Amérique, Estomac pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Bacteriosis, Infection, Stomach, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Epidemiology, Sex, Young adult, Human, Serology, Ethnic group, California, United States, North America, America, Gastric disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0580379
Code Inist : 002B05B02F. Création : 01/03/1996.