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  1. HIV infection and invasive cervical carcinoma in an Italian population : the need for closer screening programmes in seropositive patients.

    Article - En anglais


    To evaluate in an Italian population the prevalence, characteristics at first diagnosis and outcome of HIV-seropositive individuals with cervical carcinoma referred to a tertiary-care institution.

    A total of 340 women were treated over a 3-year period (186 aged<50 years).

    Six patients were found to be HIV-seropositive.


    Seropositive patients were treated according to current institutional protocols, irrespective of HIV status.

    Four underwent radiotherapy and two radical hysterectomy as primary treatment.


    Although five HIV-seropositive patients were known to be infected 13-81 months before diagnosis of cervical cancer, none had received a PAP smear in the last year and only one in the last 2 years.

    HIV patients were younger than general population, with a significant history of intravenous drug use (P=0.000001) and with more advanced disease (P=0.04).

    Two HIV-positive patients also received polychemotherapy (one adjuvant and one salvage treatment) and both completed the planned treatment.

    Within 24 months two patients had died of cancer and one of AIDS ; one is alive with AIDS and cancer and two are free of disease.


    This study confirms that in a southern European population, HIV-seropositive women present to tertiary-care institutions with more advanced disease and have a poorer prognosis than the general population.

    Strict screening programs for cervical dysplasia and cancer are warranted for HIV-seropositive patients.

    Mots-clés Pascal : SIDA, Virose, Infection, Epithélioma, Col utérus, Association, Dépistage, Séropositivité, Prévalence, Homme, Italie, Europe, Programme sanitaire, Immunopathologie, Immunodéficit, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Carcinoma, Uterine cervix, Association, Medical screening, Seropositivity, Prevalence, Human, Italy, Europe, Sanitary program, Immunopathology, Immune deficiency, Female genital diseases, Uterine cervix diseases, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0576086

    Code Inist : 002B06D01. Création : 01/03/1996.