HIV infection and invasive cervical carcinoma in an Italian population : the need for closer screening programmes in seropositive patients.
To evaluate in an Italian population the prevalence, characteristics at first diagnosis and outcome of HIV-seropositive individuals with cervical carcinoma referred to a tertiary-care institution.
A total of 340 women were treated over a 3-year period (186 aged<50 years).
Six patients were found to be HIV-seropositive.
Seropositive patients were treated according to current institutional protocols, irrespective of HIV status.
Four underwent radiotherapy and two radical hysterectomy as primary treatment.
Although five HIV-seropositive patients were known to be infected 13-81 months before diagnosis of cervical cancer, none had received a PAP smear in the last year and only one in the last 2 years.
HIV patients were younger than general population, with a significant history of intravenous drug use (P=0.000001) and with more advanced disease (P=0.04).
Two HIV-positive patients also received polychemotherapy (one adjuvant and one salvage treatment) and both completed the planned treatment.
Within 24 months two patients had died of cancer and one of AIDS ; one is alive with AIDS and cancer and two are free of disease.
This study confirms that in a southern European population, HIV-seropositive women present to tertiary-care institutions with more advanced disease and have a poorer prognosis than the general population.
Strict screening programs for cervical dysplasia and cancer are warranted for HIV-seropositive patients.
Mots-clés Pascal : SIDA, Virose, Infection, Epithélioma, Col utérus, Association, Dépistage, Séropositivité, Prévalence, Homme, Italie, Europe, Programme sanitaire, Immunopathologie, Immunodéficit, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Carcinoma, Uterine cervix, Association, Medical screening, Seropositivity, Prevalence, Human, Italy, Europe, Sanitary program, Immunopathology, Immune deficiency, Female genital diseases, Uterine cervix diseases, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0576086
Code Inist : 002B06D01. Création : 01/03/1996.