logo BDSP

Base documentaire

  1. Cost-effectiveness of Helicobacter pylori eradication for the long-term management of duodenal ulcer in Canada.

    Article - En anglais


    A 1994 National Institutes of Health consensus panel recommended that eradication of Helicobacter pylori should be first-line therapy for persons with duodenal ulcer.


    To assess the cost-effectiveness of H pylori eradication relative to alternative pharmacologic strategies in the long-term management of persons with confirmed duodenal ulcer.


    Duodenal ulcer recurrence at 6 months (symptomatic and asymptomatic) with placebo was 65.4% and 12.8% with maintenance ranitidine therapy.

    Where eradication of H pylori was successful (85% of patients), the ulcer recurrence rate to 12 months was 3.7%. Treatment with ranitidine and triple therapy to eradicate H pylori on first presentation has an expected 1-year cost of $253 with 15 symptomatic recurrences per 100 patients ; H pylori eradication by omeprazole plus amoxicillin had similar expected costs ($272) and outcomes (15 recurrences per 100 patients).

    Both of these early H pylori eradication strategies were dominant (less costly with same or better outcomes) over intermittent or continuous maintenance ranitidine therapy or delayed (after first recurrence) H pylori eradication.


    Our analysis provides economic evidence in support of the recent guidance that for persons with duodenal ulcer, early attempts to eradicate H pylori are recommended.

    Mots-clés Pascal : Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Ulcère, Duodénum, Coût, Long terme, Traitement, Complication, Homme, Canada, Amérique du Nord, Amérique, Infection, Bactériose, Appareil digestif pathologie, Intestin pathologie, Economie santé

    Mots-clés Pascal anglais : Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Ulcer, Duodenum, Costs, Long term, Treatment, Complication, Human, Canada, North America, America, Infection, Bacteriosis, Digestive diseases, Intestinal disease, Health economy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0571368

    Code Inist : 002B05B02F. Création : 01/03/1996.