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  1. Drug-related morbidity and mortality : a cost-of-illness model.

    Article - En anglais


    Preventable drug-related morbidity and mortality represent a serious medical problem that urgently requires expert attention.

    The costs to society of the misuse of prescription medications, in terms of morbidity, mortality, and treatment, can be immense.

    To date, research has primarily documented increased rates of hospitalization secondary to medication noncompliance and/or adverse drug effects.


    To develop a conceptual model of drug-related morbidity and mortality, and to estimate the associated costs in the ambulatory setting in the United States.


    A probability pathway model was developed to estimate the cost of drug-related morbidity and mortality in the United States.

    Pharmacist practitioners were surveyed to determine conditional probabilities of therapeutic outcomes owing to drug therapy.


    Drug-related morbidity and mortality was estimated to cost $76.6 billion in the ambulatory setting in the United States.

    The largest component of this total cost was associated with drug-related hospitalizations.

    When assumptions of the model were varied, the estimated cost ranged from a conservative estimate of $30.1 to $136.8 billion in a worst-case scenario.


    The cost of drug-related morbidity and mortality in the ambulatory setting in the United States is considerable and should be considered in health policy decisions with regard to pharmaceutical benefits.

    Mots-clés Pascal : Chimiothérapie, Coût, Etats Unis, Toxicité, Mortalité, Homme, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : Chemotherapy, Costs, United States, Toxicity, Mortality, Human, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0571367

    Code Inist : 002B30A01C. Création : 01/03/1996.