Glutathione S-transferase M1 (GSTM1) is active in the detoxication of a number of carcinogens, including polyaromatic hydrocarbons, such as those present in cigarette smoke.
In about 30% - 55% of individuals, depending on the ethnic group, there is a virtual absence of GSTM1 enzyme activity due to deletion of both copies of the GSTM1 gene (GSTM1 null genotype).
This genetic polymorphism of the GSTM1 gene locus has been proposed as a risk factor for lung cancer.
We conducted a case-control study of patients with incident lung cancer and population control subjects to examine the association between homozygous deletion of the GSTM1 gene and lung cancer risk among African-Americans and Caucasians.
Our data do not support a substantial association between homozygous deletion of the GSTM1 gene and the risk of lung cancer overall in this population.
However, our data do suggest an elevated risk for lighter smokers with this genotype.
Implications : Because the power of our analyses within strata of lifetime smoking history was limited, larger studies will be needed to confirm these findings.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Homme, Facteur risque, Epidémiologie, Caucasoïde, Négroïde, Noir américain, Glutathione transferase, Transferases, Enzyme, Gène, Délétion, Polymorphisme, Etats Unis, Amérique du Nord, Amérique, Echelon régional, Détoxication, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Aberration chromosomique, Chromosome anormal
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Human, Risk factor, Epidemiology, Caucasoid, Negroid, Black American, Glutathione transferase, Transferases, Enzyme, Gene, Deletion, Polymorphism, United States, North America, America, Regional scope, Detoxication, Respiratory disease, Lung disease, Bronchus disease, Chromosomal aberration, Abnormal chromosome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0570286
Code Inist : 002B11A. Création : 01/03/1996.