Recent advances in the biology and treatment of solid tumours. Symposium. Birmingham GBR, 1994/10/07.
Several factors have contributed to the improved prognosis for the survival and quality of life of children with cancer.
Childhood tumours tend to have their origin in intrinsic genetic abnormalities, and are usually disseminated by the time of diagnosis.
As a result, conventional treatments, such as ablative surgery and/or radiotherapy are rarely successful.
The finding of specific genetic mutations underlying many childhood tumours may now provide an'Achilles heel'to enable the development of highly specific therapies that are relatively non-toxic to the normal tissues undergoing rapid growth and development during childhood.
The rarity of childhood cancer and the need for multidisciplinary management make it impossible for the ordinary district hospital to deliver optimal treatment, though'maintenance'treatment and follow-up can be delivered locally as part of'shared care'with a regional centre.
These centres are members of the U.K. Children's Cancer Study Group which was formed in 1977 and now treats 75% of all cases of childhood malignancy, with sufficient numbers to run randomized clinical trials for most tumour types, often in collaboration with other national paediatric oncology groups in Europe and the U.S.A. Conclusion : Children with cancer are likely to be major beneficiaries from the recent advances in the understanding of neoplasia, many of which stem from work on paediatric malignancies.
Mots-clés Pascal : Tumeur maligne, Hémopathie maligne, Tumeur solide, Leucémie, Lymphome, Enfant, Homme, Incidence, Epidémiologie, Royaume Uni, Europe
Mots-clés Pascal anglais : Malignant tumor, Malignant hemopathy, Solid tumor, Leukemia, Lymphoma, Child, Human, Incidence, Epidemiology, United Kingdom, Europe
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0569592
Code Inist : 002B04B. Création : 01/03/1996.