Cancer incidence and mortality of patients with suspected solvent-related disorders.
Objectives The aim of this study was to study the incidence of cancer and deaths from cancer and other diseases among patients referred to the 11 clinics of occupational medicine in Sweden between 1967 and 1987 for examination because of exposure to organic solvents.
Methods The cohort comprised 5791 persons, 5283 men and 508 women.
The expected values were calculated from the national death rates and incidence rates of cancer.
Results The overall mortality rate was close to expected, but the mortality rate was decreased for diseases of the circulatory system [standardized mortality ratio (SMR) 0.7,95% confidence limit (95% CI) 0.5-4.9] and increased for suicide (SMR 2.0,95% CI 1.2-3.2).
The total cancer incidence was slightly elevated [standardized incidence ratio, and some specific cancer sites showed an increased incidence, although the lower confidence limits surpassed one.
Malignancies of the lymphohematopoietic system and cancer of the uterine cervix had an increased risk.
Conclusions The study showed an increased risk for malignancies of the hematopoietic system and the uterine cervix among patients originally examined with regard to solvent-induced disorders.
There was also an increased risk of suicide and a decreased risk of death from diseases of the circulatory system.
There was no increased risk for deaths from mental or neurological disorders.
Mots-clés Pascal : Solvant organique, Toxicité, Homme, Carcinogène, Tumeur maligne, Mortalité, Exposition professionnelle, Médecine travail, Epidémiologie, Suède, Europe, Dysplasie col utérus, Etude cohorte, Suicide, Encéphalopathie, Appareil circulatoire pathologie, Hémopathie maligne, Système nerveux pathologie
Mots-clés Pascal anglais : Organic solvent, Toxicity, Human, Carcinogen, Malignant tumor, Mortality, Occupational exposure, Occupational medicine, Epidemiology, Sweden, Europe, Cervical dysplasia, Cohort study, Suicide, Encephalopathy, Cardiovascular disease, Malignant hemopathy, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0566681
Code Inist : 002B03L04. Création : 01/03/1996.