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  1. The New York High-Risk Project : psychoses and cluster A personality disorders in offspring of schizophrenic parents at 23 years of follow-up.

    Article - En anglais


    We herein present lifetime prevalence rates of psychoses and DSM-III-R cluster A personality disorders in sample A of the New York High-Risk Project, a prospective study following offspring of parents with schizophrenia (HRSz subjects) and affective illness (HRAff subjects) and of psychiatrically normal parents (NC subjects) from midchildhood to adulthood.


    We interviewed the offspring in adulthood with the Schedule for Affective Disorders and Schizophrenia, Lifetime Version, for Axis I disorders and the Personality Disorder Examination for Axis II disorders.


    Lifetime prevalence rates (±SE) of schizophrenia and unspecified psychosis were 11.1% ±4.3% and 5.6% ±3.1%, respectively, in the HRSz group and 0% in the HRAff and NC groups.

    Rates of schizoaffective disorder subclassified as mainly schizophrenic, however, were highest in the HRAff group.

    Rates of psychotic affective disorders did not differ between the HRSz and other groups.

    Age-corrected morbidity risks were similar to lifetime prevalence rates.


    Our data strongly support a specific familial liability to narrowly defined schizophrenia that is not shared by families of probands with affective disorder.

    Schizoaffective disorder and cluster A personality disorders, however, occur in families of both schizophrenic probands and probands with affective disorder.

    Mots-clés Pascal : Schizophrénie, Psychose, Etude comparative, Trouble humeur, Parent, Descendance, Etude familiale, Trouble personnalité, Evolution, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Etude longitudinale, Long terme, Homme

    Mots-clés Pascal anglais : Schizophrenia, Psychosis, Comparative study, Mood disorder, Parent, Progeny, Family study, Personality disorder, Evolution, United States, North America, America, Epidemiology, Follow up study, Long term, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0566332

    Code Inist : 002B18H07. Création : 01/03/1996.