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  1. Efficacy of BCG vaccination of the newborn : evaluation by a follow-up study of contacts in Bangui.

    Article - En anglais

    Background

    The efficacy of Bacillus of Calmette and Guérin (BCG) vaccination given at birth is still controversial.

    We therefore conducted a study in Bangui (Central African Republic) to estimate the protection afforded over the first seven years of life by BCG administered at birth.

    Methods

    One thousand children who had lived in contact with a recently diagnosed case of contagious tuberculosis were followed up for a period of 6 months in order to detect the occurrence of tuberculosis.

    Diagnosis of tuberculosis was made through a scoring system.

    Vaccine efficacy (VE) was calculated on the basis of the relative risk of contracting tuberculosis according to vaccination status.

    Results

    The efficacy of BCG was estimated to be 71%. This result remained practically the same after changing the definition used for tuberculosis cases.

    There was no difference between the two groups in the variables measuring intensity of contact with the source of contamination, but there was a difference in age distribution.

    Vaccine efficacy adjusted for this factor was the same as the crude VE.

    Conclusion

    This study, based on a methodology that controls for most of the risks of bias inherent to field efficacy measurement, confirms the protective capacity of neonatal BCG against childhood tuberculosis.

    Therefore BCG vaccination at birth must remain a public health priority especially in countries with high incidence of the disease.

    Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Nouveau né, Homme, Efficacité, Prévention, Vaccination, BCG, Centrafrique, Afrique, Etude longitudinale, Maladie contagieuse

    Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Newborn, Human, Efficiency, Prevention, Vaccination, BCG, Central African Republic, Africa, Follow up study, Communicable disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0565017

    Code Inist : 002B05B02O. Création : 01/03/1996.



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