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  1. Incidence of human immunodeficiency virus-related and nonrelated malignancies in a large cohort of homosexual men.

    Article - En anglais


    To determine if the rates of malignancies other than Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL) are increased in human immunodeficiency virus (HIV) - infected homosexual men.

    Subjects and Methods 

    From 1984 through 1993,1,199 homosexual men were studied in the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS), an examination of the natural history of HIV infection.

    The cohort consisted of 769 HIV-seronegative (SN) participants and 430 seropositive (SP) members who were either seroprevalent at the time of enrollment or who seroconverted during the study.

    Cancer incidence data were collected through semiannual visits, phone interviews, medical records, and death certificates.

    Five thousand seven hundred eight person-years and 2,344 person-years were contributed to the study by the SN and SP men, respectively.


    In addition to 44 cases of KS, 13 NHLs, and 3 CNS lymphomas (CNSLs), 27 other malignancies occurred (three non melanoma skin cancers and eight other malignancies in the SP group, eight nonmelanoma skin cancers, and eight other malignancies in the SN group).

    Age-adjusted rates were calculated for both groups and compared with each other and with rates for the general male population in Pennsylvania.


    These findings support the hypothesis that the incidences of cancers other than KS and lymphoma are moderately increased in the setting of HIV infection and immunosuppression.

    Mots-clés Pascal : SIDA, Virose, Infection, Homme, Séropositivité, Mâle, Homosexualité, Tumeur maligne, Hémopathie maligne, Incidence, Epidémiologie, Etude cohorte, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human, Seropositivity, Male, Homosexuality, Malignant tumor, Malignant hemopathy, Incidence, Epidemiology, Cohort study, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0564349

    Code Inist : 002B06D01. Création : 01/03/1996.