Although the occupational exposure to some aromatic amines is recognized to cause bladder carcinoma, the long term effect of such exposure on the risk for disease, including other malignant tumors, remains unknown.
A total of 442 dyestuff workers exposed to one or more substances including benzidine (BZ), beta-naphthylamine (beta-N), alpha-naphthylamine (alpha-N), and dianisidine were followed completely until December 1992 (average time since first exposure, 39.4 years).
Besides the underlying cause of death, the incidence of urothelial carcinoma was determined by periodic urologic screenings.
Analyses of site-specific cancer mortality revealed a remarkable increased risk for bladder carcinoma for those engaged in BZ manufacture (standardized mortality ratio [SMR]=63.6), BZ use (SMR=27.0) and bêtaN manufacture (SMR=48.4), but not for those who were exposed to alph-N.
The increased risk of cancer mortality for other organs was not significant for any exposure classes.
The crude incidence rate per 1000 person-years of bladder carcinoma was estimated to be 8.7 for those engaged in BZ manufacture, 2.9 in BZ use, 7.7 in beta-N manufacture and 1.0 in beta-N use.
Occupational exposure to either BZ or beta-N demonstrated an extremely strong and prolonged effect on workers'risk for urothelial carcinoma, particularly for bladder carcinoma, but not for malignant neoplasms of other organs.
Mots-clés Pascal : Tumeur maligne, Homme, Amine, Composé aromatique, Exposition professionnelle, Colorant, Incidence, Epidémiologie, Etude longitudinale, Long terme, Médecine travail
Mots-clés Pascal anglais : Malignant tumor, Human, Amine, Aromatic compound, Occupational exposure, Dyes, Incidence, Epidemiology, Follow up study, Long term, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0555819
Code Inist : 002B04B. Création : 01/03/1996.