The epidemiology of large-bowel cancer suggests a role for endocrine factors in its development.
Although analytic studies have not consistently provided evidence for an association between reproductive history and large-bowel cancer, some relatively small studies have observed a reduced risk among women using postmenopausal hormone replacement therapy (HRT).
This study was planned to evaluate more precisely the relationship between HRT and the risk of colon and rectal cancers.
Compared with postmenopausal women who never used HRT, recent users had an RR of 0.54 (95% CI=0.36-0.81) for colon cancer and an RR of 0.91 (95% CI=0.54-1.55) for rectal cancer.
This inverse association was observed among users of both estrogen only and combined estrogen and progestin preparations.
Decreasing time since last use was inversely associated with colon cancer risk (P for trend<. 001).
The effect of HRT appeared to be stronger among women at lower absolute risk of colon cancer, particularly among women with lean body mass.
Use of HRT was associated with a statistically significant reduced risk of colon cancer.
In contrast, no statistically significant relationship was observed for rectal cancer.
Given the widespread use of postmenopausal hormones and the morbidity and mortality from adenocarcinoma of the bowel in women, these findings may have potentially important public health implications.
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Facteur risque, Epidémiologie, Postménopause, Traitement substitutif, Oestrogène, Progestatif, Chimiothérapie, Homme, Femelle, Ménopause, Hormone stéroïde sexuelle, Appareil digestif pathologie, Intestin pathologie, Anorectale pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Risk factor, Epidemiology, Postmenopause, Replacement therapy, Estrogen, Progestagen, Chemotherapy, Human, Female, Menopause, Sex steroid hormone, Digestive diseases, Intestinal disease, Anorectal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0554085
Code Inist : 002B13B01. Création : 01/03/1996.