We previously reported from a case-control analysis that T-cell non-Hodgkin's lymphoma (NHL) was strongly associated with human T-lymphotropic virus type I (HTLV-I) infection in Jamaica and Trinidad and that the relative risk for HTLV-I infection was very high in younger patients.
The objective of this study was to estimate the age-specific incidence rates of NHL among HTLV-I-infected and HTLV-I-uninfected adults in Jamaica and Trinidad.
Population rates of HTLV-I infection were calculated from available census reports and serosurvey data.
Incidence rates for NHL were calculated from all incident cases in Jamaica during 1984-1987 (n=135) and from all incident cases in Trinidad during 1986-1990 (n=117).
NHL incidence rates were computed according to HTLV-I status, age, sex, and tumor phenotype for each country separately and for both countries combined by weighting to the relative population size of each country.
While overall NHL incidence rates reveal that HTLV-I endemicity does not impose an exaggerated lymphoma burden on these populations, the risk for lymphoma among carriers who acquire infection early in life is dramatic and is consistent with the hypothesis that virus exposure early in life is most important for lymphomagenesis.
Studies of HTLV-I carriers known to be infected in childhood may provide insight into markers intermediate in the lymphomagnetic process. [J Natl Cancer Inst 87 : 1009-1014,1995].
Mots-clés Pascal : Lymphome non hodgkinien, Homme, Virose, Infection, Virus HTLV1, Retroviridae, Virus, Incidence, Facteur risque, Epidémiologie, Jamaïque, Antilles, Amérique Centrale, Amérique, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Human, Viral disease, Infection, HTLV-I virus, Retroviridae, Virus, Incidence, Risk factor, Epidemiology, Jamaica, West Indies, Central America, America, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0552520
Code Inist : 002B19B. Création : 01/03/1996.