Risk of cancer in relatives of prostate cancer probands.
It is estimated that there will be more than 244 000 new prostate cancer cases diagnosed and that more than 40 000 men will die of this disease during 1995.
Evidence exists for a hereditary predisposition to prostate cancer, but the proportion of cases attributable to the inheritance of a specific gene or genes is not large.
Some hereditary cancer syndromes involve more than one tumor site, and some studies have reported a familial association between prostate cancer and other cancers.
Data from two distinct study populations were studied retrospectively.
The first population consisted of 690 case patients undergoing radical prostatectomy who were not selected for family history of prostate cancer and 640 control subjects who were the spouses or female companions of the case patients.
Brothers and fathers of prostate cancer probands have a statistically significant higher risk of prostate cancer than the male first-degree relatives of control subjects (RR=1.76 ; 95% CI=1.28-2.43).
Therefore, the risk for prostate cancer is 76% higher among first-degree relatives of prostate cancer patients compared with first-degree relatives of control subjects.
Even among families that were specifically selected because of the presence of prostate cancer, risks for cancer at other sites appeared not to be increased. [J Natl Cancer Inst 87 : 991-996,1995].
Mots-clés Pascal : Tumeur maligne, Prostate, Héréditaire, Analyse risque, Epidémiologie, Site, Etude familiale, Homme, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie, Parenté premier degré
Mots-clés Pascal anglais : Malignant tumor, Prostate, Hereditary, Risk analysis, Epidemiology, Site, Family study, Human, Male genital diseases, Urinary system disease, Prostate disease, First degree relatives
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0552517
Code Inist : 002B04B. Création : 01/03/1996.