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  1. Increasing mortality from thrombotic thrombocytopenic purpura in the United States : analysis of national mortality data, 1968-1991.

    Article - En anglais

    Thrombotic thrombocytopenic purpura (TTP) is a rare disease and the epidemiologic features have been incompletely characterized.

    Because of the historically high case-fatality rate for TTP, we analyzed U.S. multiple cause-of-death mortality data with TTP listed on the death record for the period 1968-1991, in order to estimate the incidence of TTP, to characterize demographic features of the decedents, and to determine if trends in mortality correlate with findings from clinical studies showing improved survival in recent years.

    The annual age-adjusted mortality rate decreased initially and reached its lowest point at 0.4 per 1,000,000 residents for the years 1970 through 1973, and then increased steadily to 1.1 during the last 4 years of the study period, 1988 through 1991.

    We estimate the current incidence of TTP to be approximately 3.7 cases per 1,000,000 residents.

    Deaths were rare below the age of 20 years, but the age-specific mortality rate for those 20 years and older increased steadily with increasing age.

    This trend in mortality suggests that the incidence of TTP is increasing.

    Blacks, and black females in particular, are affected at a disproportionately high rate.

    The increased incidence of HIV infection and related disease may have contributed to some of the increase in TTP mortality in recent years, but it does not explain the majority of the increase, which began before the onset of the HIV epidemic.

    Mots-clés Pascal : Purpura thrombocytopénique thrombotique, Mortalité, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Homme, Thrombocyte, Hémopathie, Anémie hémolytique, Système nerveux pathologie, Appareil urinaire pathologie, Capillaire sanguin pathologie, Peau pathologie, Vaisseau sanguin peau pathologie

    Mots-clés Pascal anglais : Thrombotic thrombocytopenic purpura, Mortality, United States, North America, America, Epidemiology, Human, Platelet, Hemopathy, Hemolytic anemia, Nervous system diseases, Urinary system disease, Capillary vessel disease, Skin disease, Vascular disorders of the skin

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0550290

    Code Inist : 002B19C. Création : 01/03/1996.