Patients with human immunodeficiency virus (HIV) infection are at increased risk for bacterial pneumonia in addition to opportunistic infection.
However, the risk factors for bacterial pneumonia and its incidence in this population are not well defined.
In a multicenter, prospective, observational study, we monitored 1130 HIV-positive and 167 HIV-negative participating adults for up to 64 months for pulmonary disease.
The HIV-positive group comprised 814 homosexual or bisexual men, 261 injection-drug users, and 55 female partners of HIV-infected men.
There were 237 episodes of bacterial pneumonia among the HIV-positive participants (rate, 5.5 per 100 person-years), as compared with 6 episodes among the HIV-negative participants (rate, 0.9 per 100 person-years ; P<0.001).
The rate of bacterial pneumonia increased with decreasing CD4 lymphocyte counts (2.3,6.8, and 10.8 episodes per 100 person-years in the strata with more than 500,200 to 500, and fewer than 200 cells per cubic millimeter, respectively ; P<0.022 for each comparison).
Injection-drug users had a higher rate of bacterial pneumonia than did homosexual or bisexual men or female partners.
Bacterial pneumonia is more frequent in HIV-positive persons than in seronegative controls, and the risk is highest among those with CD4 lymphocyte counts below 200 per cubic millimeter and among injection-drug users.
(N Engl J Med 1995 ; 333 : 845-51.).
Mots-clés Pascal : SIDA, Virose, Infection, Pneumonie, Bactériose, Facteur risque, Incidence, Epidémiologie, Homme, Immunopathologie, Immunodéficit, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Pneumonia, Bacteriosis, Risk factor, Incidence, Epidemiology, Human, Immunopathology, Immune deficiency, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0543229
Code Inist : 002B06D01. Création : 01/03/1996.