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  1. Antibodies to hepatitis C virus : a cross-sectional study in patients attending a trauma unit or admitted to hospital for elective surgery.

    Article - En anglais

    Objective 

    To assess the prevalence of hepatitis C virus (HCV) antibodies in patients attending a trauma unit or admitted to hospital for elective surgery, and to identify risk factors for acquiring HCV infection.

    Design 

    A cross-sectional study.

    Setting 

    The emergency room of a Department of Orthopaedic Surgery and a hospital for elective (non-digestive) surgery.

    Patients 

    A study population of 1824 subjects (mean age 40.1±18.1 years) and sera from a control group of 4703 blood donors giving their first donation.

    Results 

    The overall prevalence of anti-HCV antibodies was 2.85% in the study population and 0.5% among blood donors (X2=64.5 ; P<0.0001).

    Anti-HCV-positivity was more common in men (3.8 versus 1.9% ; P<0.05) and in subjects with history of hepatitis (13.5 versus 2.0% ; P<0.001), exposure to a contact who had had hepatitis (12.5 versus 1.9% ; P<0.001), blood transfusion (7.8 versus 2.3% ; P<0.001), tattoos (36 versus 2.4% ; P<0.001) and intravenous drug use.

    However, one third of subjects had no risk factors for HCV infection.

    The logistic regression analysis confirmed a statistically significant association (P<0.05) between anti-HCV-positivity and intravenous drug use, tattoos, blood transfusion, a history of hepatitis and exposure to a contact who had had hepatitis.

    Conclusions 

    These results show almost a five-fold higher prevalence of anti-HCV among patients attending a trauma unit or admitted to hospital for elective surgery than among blood donors.

    Mots-clés Pascal : Infection, Virus hépatite C, Flaviviridae, Virus, Etude comparative, Prévalence, Malade, Service hospitalier, Traumatologie, Chirurgie, Donneur sang, Homme, Espagne, Europe, Virose, Foie pathologie, Appareil digestif pathologie

    Mots-clés Pascal anglais : Infection, Hepatitis C virus, Flaviviridae, Virus, Comparative study, Prevalence, Patient, Hospital ward, Traumatology, Surgery, Blood donor, Human, Spain, Europe, Viral disease, Hepatic disease, Digestive diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0541211

    Code Inist : 002B05C02G. Création : 01/03/1996.