To determine if subclinical hepatotoxicity is associated with exposure to perchloroethylene at concentrations commonly experienced in the workplace, and whether surveillance with serum hepatic transaminase activity underestimates such effects.
Methods-Hepatic parenchymal echogenicity on ultrasonography and serum hepatic transaminase activity were compared in 29 community based dry cleaning operators exposed to perchloroethylene, and a control group of 29 non-exposed laundry workers.
Perchloroethylene exposure was assessed by work history and air monitoring.
Mean hepatic transaminase activities were minimally increased in dry cleaners compared with laundry workers.
Increased alanine aminotransferase activities, between 1.0 and 1.5 times the normal limits, were found in five of 27 (19%) dry cleaners compared with one of 26 (4%) laundry workers.
Mean eight hour time weighted average perchloroethylene exposure for dry cleaners was 16 ppm, which is less than the permissible exposure limit of 100 ppm in the United States.
Conclusions-It was concluded that mild to moderate hepatic parenchymal changes occur more frequently in workers exposed to perchloroethylene than in populations not exposed to chemical solvents, and that these effects are underestimated by serum hepatic transaminase activity.
Mots-clés Pascal : Solvant organique, Ethylène(tétrachloro), Exposition professionnelle, Toxicité, Homme, Foie pathologie, Exploration ultrason, Laverie, Surveillance biologique, Transaminases, Transferases, Enzyme, Médecine travail, Appareil digestif pathologie, Nettoyage à sec
Mots-clés Pascal anglais : Organic solvent, Ethylene(tetrachloro), Occupational exposure, Toxicity, Human, Hepatic disease, Sonography, Laundry, Biological monitoring, Transaminases, Transferases, Enzyme, Occupational medicine, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0540110
Code Inist : 002B03L04. Création : 01/03/1996.