Objectives-To examine the mortality pattern and the cancer incidence in a cohort of long term smelter workers exposed to lead.
Methods-The cohort consists of 664 male lead battery workers, employed for at least three months in 1942-87.
From 1969 the values of all blood lead samples repeatedly obtained from these workers every two to three months, have been collected in a database.
The expected mortality and morbidity 1969-89 was estimated from the county rates, specified for cause, sex, five-year age groups, and calendar year.
Individual exposure matrices have been calculated and used for dose-response analyses.
The total cohort showed an increased overall mortality (standardised mortality ratio (SMR) 1.44 ; 95% confidence interval (95% CI) 1.16-1.79), an increased mortality from ischaemic heart diseases (SMR 1.72 ; 95% CI 1.20-2.42) and all malignant neoplasms (SMR 1.65 ; 95% CI 1.09-2.44).
Conclusions-A slightly increased incidence of gastrointestinal cancers was found in workers exposed to lead and employed before 1970.
The lead cohort also showed an increased mortality from ischaemic heart diseases.
These risk estimates did not show a dose-response pattern and were not associated with latency time.
The results must also be interpreted with caution because of limited numbers, and lack of dietary and smoking data.
Mots-clés Pascal : Plomb, Fusion minerai, Industrie métallurgique, Exposition professionnelle, Mortalité, Tumeur maligne, Etude cohorte, Long terme, Toxicité, Estomac, Intestin, Epidémiologie, Suède, Europe, Homme, Métal lourd, Médecine travail
Mots-clés Pascal anglais : Lead, Smelting, Metallurgical industry, Occupational exposure, Mortality, Malignant tumor, Cohort study, Long term, Toxicity, Stomach, Gut, Epidemiology, Sweden, Europe, Human, Heavy metal, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0539934
Code Inist : 002B03L05. Création : 01/03/1996.