Worker exposure to N, N-dimethylacetamide (DMAC) in an acrylic fiber manufacturing facility was measured, over a 1-year study period, by full-shift (12 hours) personnal air monitoring for DMAC and biological monitoring for levels of DMAC, N-methylacetamide (MMAC) and acetamide in post-shift spot urine samples.
Evidence of liver toxicity was assessed by serum clinical chemistry tests at least once during the study period for all 127 male workers in the two study departments and for 217 male in-plant controls with no previous or current exposure to DMAC.
If a worker's biomonitoring results exceeded one of two « trigger » values established for the study, additional serum clinical chemistry tests were conducted at weekly intervals for 3 weeks.
DMAC-exposed workers were classified as either high exposure, if one or more biomonitoring result exceeded one of the trigger values, or unspecified exposure, if none of them did.
Control-group employees were classified as no-exposure.
No significant DMAC exposure-related trends in hepatic serum clinical chemistry results were detected.
Neither transient increases in serum analyte levels after a « high » biomonitoring result nor an elevated mean level over the study period when compared with in-plant controls were observed.
These results suggest that brief threshold limit value-level exposures and chronic low-level exposure do not cause hepatotoxic clinical chemistry response.
Mots-clés Pascal : Solvant organique, Exposition professionnelle, Toxicité, Foie pathologie, Industrie textile, Fibre synthétique, Enzyme, Surveillance biologique, Médecine travail, Homme, Appareil digestif pathologie, Acétamide(N,N-diméthyl)
Mots-clés Pascal anglais : Organic solvent, Occupational exposure, Toxicity, Hepatic disease, Textile industry, Synthetic fiber, Enzyme, Biological monitoring, Occupational medicine, Human, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0537392
Code Inist : 002B03L04. Création : 01/03/1996.