Monitoring acrylic fiber workers for liver toxicity and exposure to dimethylacetamide. I : Assessing exposure to dimethylacetamide by air and biological monitoring.
Worker exposure to N, N-dimethylacetamide (DMAC) in an acrylic fiber manufacturing facility was measured, over a 1-year study period, by full-shift (12 hours) personal air monitoring for DMAC and by biological monitoring for levels of DMAC, N-methylacetamide (MMAC), and acetamide in spot urine samples.
Ninety-three of 127 male workers in seven job classifications in the solution preparation and spinning departments of the plant were monitored on the second consecutive workday after at least 3 days off for the first 10 months of the study and on both the first and second days during the study's final 2 months.
To minimize exposure misclassification due to variability in the regression relationship, a level of 35 mg MMAC/g creatinine in a postshift spot urine sample was recommended as a biomonitoring index.
Postshift urine MMAC levels did not appear to plateau at higher air levels, nor did it appear that the DMAC demethylation metabolic mechanisms became saturated at threshold limit value - level air-exposure levels.
Urine MMAC levels in postshift samples obtained the second workday appeared to be greater than levels in postshift first-day samples, but the number of days until this postshift level would plateau could not be determined from this study.
A level of 35 mg MMAC/g creatinine in a postshift urine sample obtained after as many consecutive workdays as feasible appears to be an acceptable biomonitoring index of exposure to DNAC for workers completing a 12-hour shift.
Mots-clés Pascal : Industrie textile, Fibre synthétique, Exposition professionnelle, Solvant organique, Foie pathologie, Homme, Toxicité, Surveillance biologique, Urine, Métabolite, Contrôle, Analyse quantitative, Teneur air ambiant, Appareil digestif pathologie, Médecine travail, Acétamide(N,N-diméthyl)
Mots-clés Pascal anglais : Textile industry, Synthetic fiber, Occupational exposure, Organic solvent, Hepatic disease, Human, Toxicity, Biological monitoring, Urine, Metabolite, Check, Quantitative analysis, Ambient air concentration, Digestive diseases, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0537391
Code Inist : 002B03L04. Création : 01/03/1996.