Objectives-Comparison of the suitability of two minor urinary metabolites of benzene, trans, trans-muconic acid (tt-MA) and S-phenylmercapturic acid (S-PMA), as biomarkers for low levels of benzene exposure.
Methods-The sensitivity of analytical methods of measuring tt-MA and S-PMA were improved and applied to 434 urine samples collected from 188 workers in 12 studies in different petrochemical industries and from 52 control workers with no occupational exposure to benzene.
In nine studies airborne benzene concentrations were assessed by personal air monitoring.
Strong correlations were found between tt-MA and S-PMA concentrations in samples from the end of the shift and between either of these variables and airborne benzene concentrations.
Conclusions-AIthough both tt-MA and S-PMA are sensitive biomarkers, only S-PMA allows reliable determination of benzene exposures down to 0.3 ppm (8 h TWA) due to its superior specificity.
Because it has a longer elimination half life S-PMA is also a more reliable bio-marker than tt-MA for benzene exposures during 12 hour shifts.
For biological monitoring of exposure to benzene concentrations higher than 1 ppm (8 h TWA) tt-MA is also suitable and may even be preferred due to its greater ease of measurement.
Mots-clés Pascal : Industrie pétrochimique, Exposition professionnelle, Homme, Médecine travail, Surveillance biologique, Urine, Marqueur biologique, Liquide biologique
Mots-clés Pascal anglais : Petrochemical industry, Occupational exposure, Human, Occupational medicine, Biological monitoring, Urine, Biological marker, Biological fluid
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0530610
Code Inist : 002B03L06. Création : 01/03/1996.