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  1. Exposure to polycyclic aromatic hydrocarbons in coal liquefaction workers : impact of a workwear policy on excretion of urinary 1-hydroxypyrene.

    Article - En anglais

    Objective

    This study was undertaken to assess whether contaminated personal clothing worn beneath a coverall (normal workwear) is a source of potentially significant dermal exposure to polycyclic aromatic hydrocarbons (PAHs) in coal liquefaction workers.

    Methods-An intervention study was conducted over a two week period involving 10 workers that reflected the range of activities performed at the factory.

    A cross over design was used to examine the influence of normal workwear and intervention workwear upon excretion of urinary 1-hydroxypyrene (1-OHP) and skin pad deposition of pyrene.

    Results

    The impact of intervention was noted in three ways : (1) A notable reduction (55%) in the mass of 1-OHP excreted on the first day of the intervention phase was found.

    The median reduction in mass excreted (22.7 nmol) was significant from zero at the 5% level ; (95% confidence interval (95% CI) 9.5-40.8 nmol). (2) A notable reduction (82%) in skin pad deposition of pyrene on the first day of the intervention phase was found.

    Conclusion-The results indicate that on the first day of the working week investigated, significant reductions in absorbtion (as measured by excretion of urinary 1-OHP) and deposition of PAHs (as measured by skin pad deposition of pyrene) can be effected by improvements in workwear policy.

    The impact of the improved workwear regimen was also detected by reduction in spot urinary 1-OHP concentrations, although this effect was less pronounced.

    Mots-clés Pascal : Liquide dérivé charbon, Industrie charbonnière, Composé aromatique polycyclique, Toxicité, Exposition professionnelle, Homme, Médecine travail, Surveillance biologique, Vêtement protection, Prévention, Urine, Liquide biologique, Voie externe, Contamination, Pénétration, Peau, Vetement travail

    Mots-clés Pascal anglais : Coal liquids, Coal industry, Polycyclic aromatic compound, Toxicity, Occupational exposure, Human, Occupational medicine, Biological monitoring, Safety clothing, Prevention, Urine, Biological fluid, Topical administration, Contamination, Penetration, Skin

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0530608

    Code Inist : 002B03L06. Création : 01/03/1996.