This study examined the relative contribution of occupation and smoking to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG) among a group of workers at a steel plant.
Methods-Concentrations of 1-OHPG in urine from 44 workers with jobs associated with increased air concentrations of PAHs and 40 workers with jobs with low or no exposure to PAHs were measured. 20 workers in each group were not current smokers.
Urinary 1-OHPG was measured by synchronous fluorescence spectroscopy after immunoaffinity chromatography specific for PAH metabolites.
Mean (SEM) urinary 1-OHPG concentration was 2.16 (0.42) pmol/ml urine among the 44 occupationally exposed workers compared with 0.38 (0.05) among the 40 workers with no or low exposure (P<0.0001).
Multiple linear regression showed significant differences between subjects in different PAH exposure strata and between smokers and non-smokers.
Both smoking and occupational exposure to PAHs were associated with increased concentrations of 1-OHPG in urine.
Amounts of foods containing PAHs ingested by this group of workers were relatively low and did not contribute significantly to urinary 1-OHPG concentrations.
Conclusions-These results indicate that 1-OHPG is a common urinary metabolite in people with recent occupational exposure to PAHs and is associated with both job category and estimated stratum of PAH exposure.
Mots-clés Pascal : Composé aromatique polycyclique, Toxicité, Exposition professionnelle, Acier, Industrie métallurgique, Surveillance biologique, Urine, Poste travail, Médecine travail, Homme
Mots-clés Pascal anglais : Polycyclic aromatic compound, Toxicity, Occupational exposure, Steel, Metallurgical industry, Biological monitoring, Urine, Workplace layout, Occupational medicine, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0530607
Code Inist : 002B03L06. Création : 01/03/1996.