Exposure to glycols and their renal effects in motor servicing workers.
Ten car mechanics frequently exposed to glycol-based cooling liquids were followed during a workshift.
Airborne ethylene and propylene glycol concentrations in the car mechanics'environment were measured.
The car mechanics gave urine samples after the workshift and their excretion of ethylene glycol, propylene glycol, oxalic acid, calcium and ammonia was analysed and compared to that of unexposed office workers.
Urinary succinate dehydrogenase activity and glycosaminoglycans were also measured in both groups.
Airborne ethylene and propylene glycol concentrations in the car mechanics'environment were negligible.
Urinary ethylene glycol excretion in exposed workers was significantly higher than that in unexposed workers, but propylene glycol excretion was at the same level as in controls.
In the exposed group, the excretion of the end metabolite of ethylene glycol, oxalic acid differed slightly from that of controls (36 ± 14 mmol/mol creatinine, mean ± SD, n=10).
Urinary excretion of ammonia was higher among exposed workers than office workers.
The excretion of calcium did not differ from that of controls.
A marginally decreased urinary succinate dehydrogenase activity was found in the exposed men.
The excretion of glycosaminoglycans was significantly lower in exposed workers.
Therefore, it seems that ethylene glycol is absorbed by skin contact.
The internal body burden is associated with oxaluria and increased ammoniagenesis typical of chronic acidosis.
Mots-clés Pascal : Glycol, Médecine travail, Exposition professionnelle, Automobile, Garage commercial, Refroidissement par liquide, Homme, Toxicité, Ethylène, Propanediol, Surveillance biologique, Urine, Liquide biologique, Antigel, Voie externe, Rein, Appareil urinaire pathologie, Pénétration, Peau, Absorption, Mécanicien
Mots-clés Pascal anglais : Glycol, Occupational medicine, Occupational exposure, Motor car, Commercial garage, Cooling by liquid, Human, Toxicity, Ethylene, Propanediol, Biological monitoring, Urine, Biological fluid, Antifreeze, Topical administration, Kidney, Urinary system disease, Penetration, Skin, Absorption
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0530489
Code Inist : 002B03L06. Création : 01/03/1996.