Weight loss and fluctuations in weight have been associated with increased risks of death from cardiovascular disease and from all causes.
The clinical and public health implications of these associations are unclear.
We examined the long-term relation of weight change and fluctuation in weight with mortality over a 6-year period in 6537 middle-aged Japanese American men enrolled in the Honolulu Heart Program, a prospective study (mean follow-up, 14.5 years).
Men who had a weight loss of 4.5 kg or more or who had large fluctuations in weight (or both) over a six-year period were, on average, in poorer health than their peers whose weight was more stable.
After the exclusion of subjects who died during the first five years of follow-up and after adjustment for confounding factors, a weight loss of more than 4.5 kg was associated with the risk of death from all causes, with the exception of death from cancer.
The associations between weight loss or fluctuation and mortality were partially explained by confounding factors and by the presence of preexisting disease.
However, weight loss and weight fluctuation were unrelated to death among healthy men who had never smoked.
Thus, concern about the health hazards of weight loss and variation may not be applicable to otherwise healthy people.
(N Engl J Med 1995 ; 333 : 686-92.).
Mots-clés Pascal : Relation, Perte poids, Variation périodique, Mortalité, Influence, Ethnie, Japonais, Etude cohorte, Homme, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Relation, Weight loss, Periodic variation, Mortality, Influence, Ethnic group, Japanese, Cohort study, Human, United States, North America, America
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0525527
Code Inist : 002B30A01C. Création : 01/03/1996.