The relation between body weight and overall mortality remains controversial despite considerable investigation.
We examined the association between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and both overall mortality and mortality from specific causes in a cohort of 115,195 U.S. women enrolled in the prospective Nurses'Health Study.
These women were 30 to 55 years of age and free of known cardiovascular disease and cancer in 1976.
During 16 years of follow-up, we documented 4726 deaths, of which 881 were from cardiovascular disease, 2586 from cancer, and 1259 from other causes.
In analyses adjusted only for age, we observed a J-shaped relation between body-mass index and overall mortality.
When women who had never smoked were examined separately, no increase in risk was observed among the leaner women, and a more direct relation between weight and mortality emerged (P for trend<0.001).
In multivariate analyses of women who had never smoked and had recently had stable weight, in which the first four years of follow-up were excluded, the relative risks of death from all causes for increasing categories of body-mass index.
Among women with body-mass indexes of 32.0 or higher who had never smoked, the relative risk of death from cardiovascular disease was 4.1, and that of death from cancer was 2.1, as compared with the risk among women with body-mass indexes below 19.0.
Mots-clés Pascal : Influence, Poids corporel, Facteur risque, Mortalité, Etude cohorte, Adulte jeune, Femelle, Homme
Mots-clés Pascal anglais : Influence, Body weight, Risk factor, Mortality, Cohort study, Young adult, Female, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0525526
Code Inist : 002B30A01C. Création : 01/03/1996.