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  1. "Marriage to a smoker" may not be a valid marker of exposure in studies relating environmental tobacco smoke to risk of lung cancer in Japanese non-smoking women.

    Article - En anglais

    There is no direct evidence that workplace environmental tobacco smoke (ETS) increases lung cancer risk.

    Demands for regulation of workplace smoking are based on studies reporting increased risk in non-smoking women whose husbands smoke.

    Although denying smoking can artificially elevate risk estimates, and although many studies reporting an increase have been conducted in Asia, no previous study of smoking habit misclassification has been conducted there.

    In this study 400 married Japanese women answered questions on smoking and ETS exposure and supplied urine for cotinine analysis.

    Of 106 with a cotinine/creatinine ratio (CCR) indicating current smoking (>100 ng/mg), 22 reported never smoking.

    Japanese epidemiological studies using « marriage to a smoker » to index ETS exposure may therefore have compared groups with similar ETS exposure, suggesting that associations reported between lung cancer and this index in some of these studies may result from bias.

    While other biases, including confounding, may also be important, bias resulting from smoking misclassification combined with husband/wife smoking concordance is shown to be of major concern.

    The high misclassification rates in Japan, much higher than in Western populations, undermine conclusions from epidemiological studies conducted there.

    Mots-clés Pascal : Tabagisme passif, Tumeur maligne, Bronchopulmonaire, Homme, Femelle, Conjoint, Toxicité, Cotinine, Marqueur biologique, Biais méthodologique, Epidémiologie, Japon, Asie, Médecine travail, Poumon pathologie, Appareil respiratoire pathologie

    Mots-clés Pascal anglais : Passive smoking, Malignant tumor, Bronchopulmonary, Human, Female, Spouse, Toxicity, Biological marker, Methodological bias, Epidemiology, Japan, Asia, Occupational medicine, Lung disease, Respiratory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0523115

    Code Inist : 002B03E. Création : 01/03/1996.