Prognosis and life expectancy in chronic liver disease.
The aim of the present study was to define prognosis and life expectancy in patients with chronic liver disease of different etiologies and to relate them to an age-and sex-matched normal population.
After a follow-up of 15 years, life expectancy of 620 patients with chronic liver disease was retrospectively calculated and compared with an age-and sex-matched normal population.
Among patients with cirrhosis, prognosis was dependent upon the Child classification (P=0.001).
Patients with alcoholic cirrhosis and fatty liver disease were younger (P=0.01) and had a lower life expectancy than patients with other causes of chronic liver disease (P=0.004).
Patients with hepatitis B and hepatitis C cirrhosis showed a comparable prognosis and a significantly lower life expectancy than the age-and sex-matched population.
Cryptogenic and autoimmune liver diseases showed a comparable life expectancy but a significantly shorter life expectancy than the normal population.
In patients with alpha1-antitrypsin deficiency-associated cirrhosis, a high viral coinfection rate was found (P=0.01).
For patients with noncirrhotic hemochromatosis, prognosis was poorer than that for the age-and sex-matched population.
In patients with asymptomatic primary biliary cirrhosis, chronic persistent hepatitis B, and alpha1-antitrypsin deficiency without cirrhosis, life expectancy was equal to that of the normal population.
Mots-clés Pascal : Maladie, Chronique, Foie, Pronostic, Survie, Etude comparative, Etude statistique, Homme, Foie pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Disease, Chronic, Liver, Prognosis, Survival, Comparative study, Statistical study, Human, Hepatic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0518242
Code Inist : 002B13C03. Création : 01/03/1996.