The aim of the present study was to define prognosis and life expectancy in patients with chronic liver disease of different etiologies and to relate them to an age-and sex-matched normal population.
After a follow-up of 15 years, life expectancy of 620 patients with chronic liver disease was retrospectively calculated and compared with an age-and sex-matched normal population.
Among patients with cirrhosis, prognosis was dependent upon the Child classification (P=0.001).
Patients with alcoholic cirrhosis and fatty liver disease were younger (P=0.01) and had a lower life expectancy than patients with other causes of chronic liver disease (P=0.004).
Patients with hepatitis B and hepatitis C cirrhosis showed a comparable prognosis and a significantly lower life expectancy than the age-and sex-matched population.
Cryptogenic and autoimmune liver diseases showed a comparable life expectancy but a significantly shorter life expectancy than the normal population.
In patients with alpha1-antitrypsin deficiency-associated cirrhosis, a high viral coinfection rate was found (P=0.01).
For patients with noncirrhotic hemochromatosis, prognosis was poorer than that for the age-and sex-matched population.
In patients with asymptomatic primary biliary cirrhosis, chronic persistent hepatitis B, and alpha1-antitrypsin deficiency without cirrhosis, life expectancy was equal to that of the normal population.
Mots-clés Pascal : Maladie, Chronique, Foie, Pronostic, Survie, Etude comparative, Etude statistique, Homme, Foie pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Disease, Chronic, Liver, Prognosis, Survival, Comparative study, Statistical study, Human, Hepatic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0518242
Code Inist : 002B13C03. Création : 01/03/1996.